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To optimize colonization and persistence in the tick midgut, Borrelia has evolved complex strategies, how to exploit the tick midgut milieu (Figure 2)

Figure 8)

Analysis of pregnancy outcomes indicated that the home quarantine group had a higher prevalence of GDM A1 than GDM A2, and there was also a tendency for pre-eclampsia incidence to increase

It highlighted the physiological function and several molecular pathways of astroglia in the association of Na + ion involvement, which includes Na + activated Na x channels, Na + -dependent glutamate transporters EAAT1/SLC1A6, and EAAT2/SLC1A2, Cystine/glutamate antiporter Sxcconsisting of xCT/SCL7A11 and 4F2hc/SLC3A2 proteins, Na + -dependent GABA transporter GAT3/SLC6A11, Na + -dependent glutamine transporters, Glycine Na + -dependent glycine transporters GlyT1/SLC6A9, Na + -dependent concentrative nucleoside transporters CNT2/SLC28A2 and CNT3/SLC28A3, Na + -K + pump (NKA), Na + -K + -Cl co-transporter 1 NKCC1/SLC12A2, Na + -K + -Cl co-transporter 1 NKCC1/SLC12A2, Na + -H + exchanger NHE1/SLC9A1, Na + -HCO 3 transporter NBCe1/SLC4A4, Na + -Ca 2+ exchanger NCX1/SLC8A1, NCX2/SLC8A2 and NCX3/SLC8A3 (Verkhratsky et al., 2017)